#WINNONLIN SOFTWARE FREE DOWNLOAD TRIAL#

Phoenix/NLME, WinBUGS, SAS, Matlab, R-packages, others WinNonlin, Kinetica, others NCA (Cmax, AUC, T>MIC Any (!) estimation tool Exposure response Safety model / relationship (Population) PK model (Population) PD model Berkeley Madonna Any tool for sim.

#WINNONLIN SOFTWARE FREE DOWNLOAD TRIAL#

AuthorвЂ™s Copyright В© All rights reserved.ДҐ Tasks and Tools Optimal dosing NCA (Cmax, AUC, T>MICД®xposure response Safety model / relationship Simulation of drug concentrations (Population) PK model (Population) PD model Predict effect and safety for in vitro and animal models, and ultimately patients Optimal dosing Robust Clinical Trial design Optimal trial design пѓ PK/PD model Individual patient Patient population AuthorвЂ™s Copyright В© All rights reserved.Д¦ Optimal dosing NONMEM, ADAPT, S-ADAPT, Pmetrics/USC*PACK, Monolix, Evaluate the robustness of a clinical trial design. Propose a clinical trial design that provides safe and effective regimens and optimally informs a PK or PK/PD model for patients. Account for MIC / pathogen, renal function, other diseases, etc.

Achieve therapeutic target goals most precisely in an individual patient. пѓ To design mechanistically optimized (combination) dosage regimens. Evaluate proposed mechanisms of action, resistance, and synergy. Identify covariates that affect dosing (e.g. Develop a population PK or PK/PD model to: Propose optimized empiric dosage regimens for a patient population via Monte Carlo simulations. Simulate antibiotic concentrations for dosage regimens in mice or humans. Fit an exposure-response (or exposure-toxicity) relationship correlating fAUC/MIC with bacterial counts at 24 h, for example. There is no single tool which does it all! Communication of approach & results is critical! AuthorвЂ™s Copyright В© All rights reserved.Д¤ Relevant tasks for anti-infective PK/PDДetermine Cmax, AUC, T>MIC, clearance (CL), volume (Vd), and other parameters via non-compartmental analysis (NCA). Often, several tools can yield suitable results. Plausibility checks! A model without a task is not very useful. Secondary, as long as one of suitable tools is chosen and used by a skilled person. Outline вЂњThe right taskвЂќ Software tools for Non-compartmental analysis Exposure-response & exposure-toxicity relationships Simulation of PK and PK/PD profiles Estimation of PK and PK/PD model parameters Optimal dosing of a patient population (Monte Carlo simulation) Optimal dosing of individual patients Optimal clinical trial design Clinical trial simulation Concluding remarks AuthorвЂ™s Copyright В© All rights reserved.ДЈ Most appropriate tool for the required taskДefine and discuss the objective(s) Evaluate the time available Gain a thorough understanding of the data Discuss / select relevant approaches пѓ May need to revisit the approach / time Select the most suitable software tool and data analytical approach. 1 Population PK/PD modelling: Software ChoicesД®SCMID Postgraduate Technical Workshop Advanced Antimicrobial Pharmacokinetic and Pharmacodynamic Modelling & Simulation Population PK/PD modelling: Software Choices Monday, October 6th, 2014 Liverpool, UK JГјrgen B Bulitta, PhD Senior Research Fellow Monash University, Melbourne, Australia Adjunct Assistant Professor SUNY Buffalo, NY, USA AuthorвЂ™s Copyright В© All rights reserved.Дў AuthorвЂ™s Copyright В© 2014.

Winnonlin software free download